AZD-9291 mesylate

CAS No. 1421373-66-1

AZD-9291 mesylate ( Osimertinib mesylate;Mereletinib mesylate;AZD9291 mesylate;AZD 9291 mesylate )

Catalog No. M11763 CAS No. 1421373-66-1

A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 50 In Stock
50MG 72 In Stock
100MG 87 In Stock
200MG 104 In Stock
500MG 120 In Stock
1G 140 In Stock

Biological Information

  • Product Name
    AZD-9291 mesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
  • Description
    A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively; weak activity against wt EGFR (IC50=184 nM); inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro; exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.Lung Cancer Approved
  • Synonyms
    Osimertinib mesylate;Mereletinib mesylate;AZD9291 mesylate;AZD 9291 mesylate
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR(L858R);EGFR(L858R/T790M);EGFRL858R/T790M;EGFRL858R
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    1421373-66-1
  • Formula Weight
    595.71
  • Molecular Formula
    C29H37N7O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O
  • Chemical Name
    2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
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